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Loperamide may provide short-term relief for mild to moderate diarrhoea associated with retatrutide, but should not be used if there is blood or mucus in the stool, high fever, or suspected antibiotic-associated colitis
Some patients see modest improvements in muscle density during treatment
Food and Drug Administration approved tirzepatide weekly injections for chronic weight management in adults who are overweight or have obesity, with at least one weight-related condition (such as high blood pressure, type 2 diabetes or high cholesterol), in addition to a reduced calorie diet and increased physical activity in November 2023
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